https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47742 n = 10) were compared with PTSD participants with minimal co-morbidities (n = 10). The 2D MRS identified statistically significant increases in the total spectral region containing both free substrate fucose and fucosylated glycans of 31% (P = 0.0013), two of multiple fucosylated glycans (Fuc IV and VI) were elevated by 48% (P = 0.002), and 41% (P = 0.02), respectively, imidazole was increased by 12% (P = 0.002), and lipid saturation was increased by 12.5% (P = 0.009). This is the first evidence of fucosylated glycans, reported in animals to be involved in learning and memory, to be affected in humans with PTSD.]]> Wed 25 Jan 2023 15:28:52 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53604 75% (AUC = 0.79, SE = 0.014). Discrimination between ISO lesions and cNAWM was accomplished with an accuracy of >69% (AUC = 0.74, SE = 0.018), while discrimination between BH lesions and cNAWM was achieved at an accuracy of >80% (AUC = 0.87, SE = 0.021). Conclusions: Our results highlight the potential of APTw imaging for use as a non-invasive technique that is able to provide essential molecular information to clinicians and researchers so that the stages of inflammation and degeneration in MS lesions can be better characterized.]]> Wed 07 Feb 2024 14:34:19 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33281 Tue 25 Sep 2018 11:08:20 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53309 .05). Compared to HCs, both RRMS cohorts showed volume changes in white matter (−13%), gray matter (−16%), and cerebral spinal fluid (CSF) (+17-23%), as well as reduced NAA (−17%, p =.001, hippocampus), (−7%, p =.001, PCG), and (−9%, p =.001, PFC). MRI/S metrics in three regions were moderately correlated with cognition and fatigue functions. Conclusion: While both treatment arms showed overall similar volumetric and neurometabolic profiles, longitudinal studies are warranted to clarify neurometabolic changes and associations with treatment efficacy.]]> Tue 21 Nov 2023 12:02:21 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44317 Tue 11 Oct 2022 16:19:33 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36572 Tue 09 Jun 2020 11:40:47 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52120 Thu 28 Sep 2023 15:04:45 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53980 pFDR ≤ 0.001; false-detection-rate (FDR)-corrected). There was a significant decrease in WML diffusivities and an increase in FA over the follow-up period in most TOIs (pFDR ≤ 0.001). Additionally, there were no differences in DTI parameters across treatment groups. AD and MD were positively correlated with fatigue scores (r ≤ 0.33, p ≤ 0.01) in NAWM-TOIs, while disability (EDSS) was negatively correlated with FA in most NAWM-TOIs (|r|≤0.31, p ≤ 0.01) at both time points. Disability scores correlated with all diffusivity parameters (r ≤ 0.29, p ≤ 0.01) in most WML-TOIs at both time points. Conclusion: Statistically significant changes in diffusion metrics in WML might be indicative of integrity improvement over two years in CTS tracts in clinically stable pw-RRMS. This finding represents structural changes within lesioned tracts. Measuring diffusivity in pw-RRMS affected tracts might be a relevant measure for future remyelination clinical trials.]]> Thu 25 Jan 2024 12:56:51 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31520 Sat 24 Mar 2018 08:43:53 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24704 85% loss of 'pore' function of the P2X7 receptor measured by ATP-induced ethidium uptake. Analysis shows Arg307Gln always occurred with 270His suggesting a single 307Gln-270His haplotype which confers dominant negative effects on P2X7 function and protection against MS. Modelling based on the homologous zP2X4 receptor showed Arg307 is located in a region rich in basic residues located only 12Å from the ligand binding site. Our data show the protective effect against MS of a rare genetic variant of P2RX7 with heterozygotes showing near absent proinflammatory 'pore' function.]]> Sat 24 Mar 2018 07:10:52 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42377 Mon 22 Aug 2022 14:29:24 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53246 Mon 20 Nov 2023 10:14:36 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54737 90 % accuracy in this cohort (AUC=0.92, SE=0.86 - 0.94). Conclusion: Multi-modal MRI signatures can predict cognitive decline in a cohort of pwMS over 5 years with high accuracy. Future studies will benefit from the inclusion of even more MR modalities e.g., functional MRI, quantitative susceptibility mapping, magnetisation transfer imaging, as well as other potential predictors e.g., genetic and environmental factors. With further validation, this signature could be used in future trials with high-risk patients to personalise the management of cognitive decline in pwMS, even in the absence of relapses.]]> Mon 11 Mar 2024 14:19:33 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51918 Fri 22 Sep 2023 10:40:32 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54701 Fri 08 Mar 2024 12:07:53 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49119 Fri 05 May 2023 11:46:07 AEST ]]>